FACULTY
Adjunct
Associate Professor
B.A., Beloit College, Beloit, Wis.
Ph.D., Baylor College of Medicine, Houston, TX.
The Nathan Kline Institute
140 Old Orangeburg Rod
Orangeburg, NY 10962
Office Phone: 845-398-6601
Email: smiley@nki.rfmh.org
• Research Interests:My laboratory is investigating brain anatomy, neuropathology and hemispheric asymmetry in normal and schizophrenia patients. Schizophrenia is characterized by neuroanatomical changes that seem to reflect both developmental and molecular abnormalities. At present, the precise nature of these changes is poorly characterized. This information is essential to produce animal models of schizophrenia and to finally understand the cause of this disease. Our goal is to more specifically define the nature of these changes, and to determine their regional expression across different areas and hemispheres of the cerebral cortex. We are especially interested in auditory cortex because it is functionally well defined, and it has hemispheric asymmetries that may be altered in this disease.
Several approaches are being used to investigate the anatomy and neurochemistry of the cerebral cortex. Over the past several years we have established a collection of tissue from 60 postmortem human brains for these studies. Quantitative methods are being developed and used to investigate different anatomical features. These employ several fully automated microscopy systems integrated with computer imaging stations. Histochemical methods are being used to identify molecular changes in neurons and glia, and to map these changes across areas of the cerebral cortex.
In addition to studies in humans, we are using tract-tracing methods in non-human primates to tease apart the circuitry of auditory association areas. More recently, we are developing rodent models of schizophrenia, using histochemical methods to investigate changes seen after different pharmacological treatments.
Recent publications:Dias, E.C., T. McGinnis, J.F. Smiley, J.J. Foxe, C.E. Schroeder, D.C. Javitt. (2005) Changing plans: Correlates of executive control in monkey and human frontal cortex. Experimental Brain Res. In press.
K. G. Fu, T. A. Johnson, A. S. Shah, L. Arnold, J. Smiley, T. A. Hackett, P. Garraghty and C. E. Schroeder, (2003). Auditory cortical neurons respond to somatosensory stimulation. J. Neurosci. 23:7510-7515.
Saito, M.. Smiley, J., Toth, R., Vadasz, C. (2002).Microarray Analysis of Gene Expression in Rat Hippocampus after Chronic Ethanol Treatment. Neurochem. Res. 27:1217-1225
Balla, A., Koneru, R., Smiley, J.F., Sershen, H., Javitt, D.C. (2001) Continuous phencyclidine treatment induces schizophrnia-like hyperreactivity of striatal dopamine release. Neuropsychopharmacology: 25:157-64.
Schroeder, C., R.L. Lindsley, C. Specht, A. Marcovici, J.F. Smiley, and D.C. Javitt (2001) Somatosensory input to auditory association cortex in macaques: An anatomical basis for somatosensory-auditory integration. J. Neurophys.. 85:1322-1327.
Smiley, J.F., J.P. Mcginnis, and D.C. Javitt (2000) Nitric oxide synthase neurons are subsets of the somatostatin, neuropeptide Y, and calbindin expressing cells of the monkey neocortex. Brain Research. 863:205-212.
Ghoshal, N., J.F. Smiley, A.J. DeMaggio, M.F. Hoekstra, E.J. Cochran, L.I. Binder, and J. Kuret. (1999) A new molecular link between the fibrillar and granulovacuolar lesions of Alzheimer’s disease. Am. J. Pathol. 155:1163-1172.
Smiley, J.F., M. Subramanian, and M.-M. Mesulam (1999). Monoaminergic-Cholinergic Interactions in the Primate Basal Forebrain. Neuroscience 93:817-829.
Smiley, J.F., A.I. Levey, and M.-M. Mesulam (1999) m2 Muscarinic receptor immunolocalization in cholinergic cells of the monkey basal forebrain and striatum. Neuroscience. 90:803-814.
Smiley, J.F., and M.-Marsel Mesulam (1999) Cholinergic neurons of the nucleus basalis of Meynert (Ch4) receive cholinergic, catecholaminergic, and GABAergic synapses: An electron microscopic investigation in the monkey. Neuroscience 88:241-251.
Smiley, J.F., A.I. Levey, and M.-M. Mesulam (1998) Infracortical interstitial cells concurrently expressing m2-muscarinic receptors, AChE, and NADPH-d in the human and monkey cerebral cortex. Neuroscience. 84:755-769.
Guillozet, A. L., J. F. Smiley, D.C. Mash and M.-M. Mesulam (1997) Butyrylcholinesterase (BChE) in the life cycle of amyloid plaques. Annals of Neurology 42:909-918.
Smiley, J.F., F. Morrell and M.-M. Mesulam (1997) Cholinergic Synapses in Human Cerebral Cortex: An Ultrastructural Study in Serial Sections. Exp. Neurol. 144:361-368.
